Expression of GRXCR1 in cancer - Summary

CANCER ATLAS

Gene description

Glutaredoxin, cysteine rich 1

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Ovarian cancer

STAINING SUMMARY

HPA040824

GENE INFORMATION
Gene name	GRXCR1 (HGNC Symbol)
Synonyms	DFNB25, PPP1R88
Description	Glutaredoxin, cysteine rich 1 (HGNC Symbol)
Entrez gene summary	This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010]
Chromosome	4
Cytoband	p13
Chromosome location (bp)	42893267 - 43030658
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000215203 (version 83.38)
Entrez gene	389207
UniProt	A8MXD5 (UniProt - Evidence at protein level)
neXtProt	NX_A8MXD5
Antibodypedia	GRXCR1 antibodies

PROTEIN BROWSER

GRXCR1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRXCR1-001 ENSP00000382670 ENST00000399770	A8MXD5 [Direct mapping] Glutaredoxin domain-containing cysteine-rich protein 1 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0003674 [molecular_function] GO:0007605 [sensory perception of sound] GO:0009055 [electron carrier activity] GO:0010923 [negative regulation of phosphatase activity] GO:0015035 [protein disulfide oxidoreductase activity] GO:0032420 [stereocilium] GO:0042491 [auditory receptor cell differentiation] GO:0045454 [cell redox homeostasis] GO:0048563 [post-embryonic organ morphogenesis] GO:0048839 [inner ear development] GO:0055114 [oxidation-reduction process] GO:0060091 [kinocilium] GO:0060118 [vestibular receptor cell development] GO:0060119 [inner ear receptor cell development] GO:0060122 [inner ear receptor stereocilium organization] Show all	290 aa 32.3 kDa	No	0