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Fraction of cells in few cases of melanomas, ovarian, cervical and testicular cancers exhibited weak to moderate cytoplasmic and/or nuclear immunoreactivity. Rare duct carcinomas of breast and stomach cancers were strongly stained. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
KBTBD13 (HGNC Symbol)
Synonyms
hCG_1645727, NEM6
Description
Kelch repeat and BTB (POZ) domain containing 13 (HGNC Symbol)
Entrez gene summary
The gene belongs to a family of genes encoding proteins containing a BTB domain and several kelch repeats. The BTB domain functions as a protein-protein interaction module, which includes an ability to self-associate or to interact with non-BTB domain-containing proteins. The kelch motif typically occurs in groups of five to seven repeats, and has been found in proteins with diverse functions. Known functions of these family members include transcription regulation, ion channel tetramerization and gating, protein ubiquitination or degradation, and cytoskeleton regulation. The exact function of this family member has yet to be determined. [provided by RefSeq, Jun 2010]