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Most cancer tissues displayed moderate to strong cytoplasmic and extracellular positivity. Several cases of lymphomas, squamous cell carcinomas, prostate- and colorectal cancers were negative.
GENE INFORMATION
Gene name
SERPINA3
Synonyms
Description
Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (EntrezGene)
Entrez gene summary
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]