Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence HPA evidence UniProt evidence MS evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location RNA tissue category RNA TS RNA TS TPM TPM max in non-specific AACS ACSF1, FLJ12389, SUR-5 ENSG00000081760 Acetoacetyl-CoA synthetase 12 125065379-125143333 Enzymes, Predicted membrane proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA058815 Approved Approved Vesicles Expressed in all breast: 54.1 AARS CMT2N ENSG00000090861 Alanyl-tRNA synthetase 16 70252295-70289543 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB034261, HPA040870, HPA044223 Supported Validated Cytosol Expressed in all parathyroid gland: 174.6 AARS2 AARSL, bA444E17.1, KIAA1270 ENSG00000124608 Alanyl-tRNA synthetase 2, mitochondrial 6 44299654-44313326 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA035636, HPA061396 Approved Validated Mitochondria Mixed parathyroid gland: 11.1 ACACA ACAC, ACC, ACC1 ENSG00000278540 Acetyl-CoA carboxylase alpha 17 37084988-37406818 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB013715, HPA036650, HPA063018 Approved Supported Nucleoli fibrillar center
Actin filaments
Cytosol Mixed breast: 28.4 ACACB ACC2, ACCB, HACC275 ENSG00000076555 Acetyl-CoA carboxylase beta 12 109116595-109268226 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA006554 Supported Tissue enriched 6 adipose tissue: 194.0 parathyroid gland: 30.2 ACSBG1 BG1, BGM, FLJ30320, hBG1, hsBG, KIAA0631, MGC14352 ENSG00000103740 Acyl-CoA synthetase bubblegum family member 1 15 78167468-78245688 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at transcript level Evidence at transcript level Evidence at protein level HPA041642, CAB045955, HPA058869 Approved Approved Vesicles Tissue enhanced 0 cerebral cortex: 25.7;skin: 13.3 adrenal gland: 8.1 ACSBG2 BGR, DKFZp434K1635, PRTD-NY3 ENSG00000130377 Acyl-CoA synthetase bubblegum family member 2 19 6135247-6193094 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA043421, HPA051013 Supported Uncertain Cytosol Tissue enriched 709 testis: 291.8 cerebral cortex: 0.4 ACSL1 ACS1, FACL1, FACL2, LACS, LACS1, LACS2 ENSG00000151726 Acyl-CoA synthetase long-chain family member 1 4 184755595-184826818 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA011316, HPA011964 Supported Supported Nucleus
Mitochondria Expressed in all adipose tissue: 820.6 ACSL3 ACS3, FACL3, PRO2194 ENSG00000123983 Acyl-CoA synthetase long-chain family member 3 2 222860934-222944639 Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA011315, HPA071021 Uncertain Approved Nucleoli
Lipid droplets Expressed in all parathyroid gland: 670.1 ACSL4 ACS4, FACL4, LACS4, MRX63, MRX68 ENSG00000068366 Acyl-CoA synthetase long-chain family member 4 X 109624244-109733403 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA000286, HPA005552 Supported Approved Golgi apparatus
Mitochondria Expressed in all cervix: 70.3 ACSL5 ACS2, ACS5, FACL5 ENSG00000197142 Acyl-CoA synthetase long-chain family member 5 10 112374018-112428380 Enzymes, Plasma proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA007162, CAB062546 Supported Supported Nucleus
Mitochondria Expressed in all small intestine: 469.9 ACSL6 ACS2, FACL6, KIAA0837, LACS2, LACS5 ENSG00000164398 Acyl-CoA synthetase long-chain family member 6 5 131949973-132012243 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at transcript level Evidence at protein level HPA040470 Uncertain Group enriched 6 bone marrow: 18.0;cerebral cortex: 62.1;parathyroid gland: 22.1;seminal vesicle: 28.7;testis: 51.2 adrenal gland: 6.5 ACSM1 BUCS1, MACS1 ENSG00000166743 Acyl-CoA synthetase medium-chain family member 1 16 20623237-20698890 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at transcript level Evidence at protein level HPA046291 Uncertain Tissue enriched 55 breast: 293.3 prostate: 5.2 ACSM2A A-923A4.1, ACSM2, MGC150530 ENSG00000183747 Acyl-CoA synthetase medium-chain family member 2A 16 20451461-20487667 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA057699 Supported Group enriched 578 kidney: 284.3;liver: 185.7 cerebral cortex: 0.4 ACSM2B ACSM2, HXMA, HYST1046 ENSG00000066813 Acyl-CoA synthetase medium-chain family member 2B 16 20536226-20576427 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA057699 Supported Group enriched 85 kidney: 423.8;liver: 261.6 thyroid gland: 4.0 ACSM3 SA, SAH ENSG00000005187 Acyl-CoA synthetase medium-chain family member 3 16 20610243-20797581 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA041013 Uncertain Tissue enhanced 0 liver: 93.0 kidney: 89.9 ACSM4 ENSG00000215009 Acyl-CoA synthetase medium-chain family member 4 12 7304284-7328724 Enzymes, Predicted membrane proteins Evidence at transcript level Evidence at transcript level Evidence at transcript level HPA049895 Uncertain Tissue enhanced 0 ovary: 2.5;testis: 2.6 spleen: 1.2 ACSM5 FLJ20581 ENSG00000183549 Acyl-CoA synthetase medium-chain family member 5 16 20409534-20441336 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA041435 Uncertain Tissue enhanced 0 liver: 142.5 kidney: 29.2 ACSM6 bA310E22.3, C10orf129 ENSG00000173124 Acyl-CoA synthetase medium-chain family member 6 10 95194200-95228928 Enzymes, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at transcript level Evidence at protein level HPA044593 Uncertain Tissue enhanced 0 stomach: 1.7 urinary bladder: 0.6 ACSS1 ACAS2L, AceCS2L, dJ568C11.3, MGC33843 ENSG00000154930 Acyl-CoA synthetase short-chain family member 1 20 25006230-25058980 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA041014, HPA043228 Approved Expressed in all placenta: 165.1 ACSS2 ACAS2, AceCS, ACS, ACSA, dJ1161H23.1 ENSG00000131069 Acyl-CoA synthetase short-chain family member 2 20 34872146-34927962 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA004141 Approved Approved Nucleoplasm
Vesicles
Cytosol Mixed adipose tissue: 55.9 ACSS3 FLJ21963 ENSG00000111058 Acyl-CoA synthetase short-chain family member 3 12 80936414-81261205 Enzymes, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA039353, HPA047956, HPA061517 Approved Approved Mitochondria Mixed parathyroid gland: 33.0 ADSS ENSG00000035687 Adenylosuccinate synthase 1 244408494-244452134 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA024400 Supported Supported Plasma membrane
Cytosol Expressed in all testis: 116.4 ADSSL1 FLJ38602 ENSG00000185100 Adenylosuccinate synthase like 1 14 104724186-104747325 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enriched 7 skeletal muscle: 428.0 heart muscle: 64.7 ASNS ENSG00000070669 Asparagine synthetase (glutamine-hydrolyzing) 7 97852118-97872542 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA004924, HPA029318, HPA064737 Approved Validated Cytosol Expressed in all cerebral cortex: 74.3 ASS1 ASS, CTLN1 ENSG00000130707 Argininosuccinate synthase 1 9 130444929-130501274 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA020896, HPA020934 Supported Approved Nucleoplasm
Cytosol Tissue enhanced 0 kidney: 1253.5;liver: 1027.3 fallopian tube: 258.7 CAD ENSG00000084774 Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 2 27217390-27243943 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB007781, HPA057266, HPA069341 Supported Supported Nucleoplasm Expressed in all skin: 22.0 CARNS1 ATPGD1, KIAA1394 ENSG00000172508 Carnosine synthase 1 11 67414968-67425607 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA038569 Approved Group enriched 9 cerebral cortex: 37.2;skeletal muscle: 25.9 heart muscle: 3.4 CARS CARS1 ENSG00000110619 Cysteinyl-tRNA synthetase 11 3000922-3057613 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA002383, HPA002384, CAB075734, CAB075735, CAB075736, CAB075737 Supported Validated Cytosol Expressed in all thyroid gland: 28.2 CARS2 FLJ12118 ENSG00000134905 Cysteinyl-tRNA synthetase 2, mitochondrial (putative) 13 110641412-110713603 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA041776 Uncertain Approved Nucleoplasm
Mitochondria Expressed in all cervix: 28.3 CPS1 ENSG00000021826 Carbamoyl-phosphate synthase 1, mitochondrial 2 210477682-210679107 Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB003781, HPA021400 Supported Approved Nucleoli Group enriched 24 duodenum: 241.2;liver: 697.3;small intestine: 147.2 testis: 15.2 CTPS1 CTPS ENSG00000171793 CTP synthase 1 1 40979335-41012565 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB017111, HPA051322 Approved Supported Actin filaments
Cytosol Expressed in all smooth muscle: 79.3 CTPS2 ENSG00000047230 CTP synthase 2 X 16588003-16712936 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA017437 Uncertain Approved Nucleoplasm
Cytosol Expressed in all parathyroid gland: 27.6 DARS ENSG00000115866 Aspartyl-tRNA synthetase 2 135906677-135986100 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA020451, HPA029804, HPA029805 Supported Validated Cytosol Expressed in all thyroid gland: 90.6 DARS2 FLJ10514 ENSG00000117593 Aspartyl-tRNA synthetase 2, mitochondrial 1 173824503-173858546 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA026506, HPA026528 Supported Supported Nucleus
Mitochondria Expressed in all parathyroid gland: 24.9 DPH6 ATPBD4, MGC14798 ENSG00000134146 Diphthamine biosynthesis 6 15 35217345-35546193 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA042976, HPA055496 Approved Validated Nucleus
Nucleoli Expressed in all thyroid gland: 18.0 EARS2 KIAA1970, MSE1 ENSG00000103356 Glutamyl-tRNA synthetase 2, mitochondrial 16 23522014-23557731 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA043289, HPA043633 Approved Supported Nucleoplasm
Mitochondria Expressed in all parathyroid gland: 32.3 EPRS EARS, GLUPRORS, PARS, QARS, QPRS ENSG00000136628 Glutamyl-prolyl-tRNA synthetase 1 219968601-220046658 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA026490, HPA030052 Supported Validated Cytosol Expressed in all parathyroid gland: 118.2 FARS2 dJ236A3.1, FARS1 ENSG00000145982 Phenylalanyl-tRNA synthetase 2, mitochondrial 6 5261044-5771580 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA018148, HPA028836 Approved Approved Plasma membrane Expressed in all thyroid gland: 24.3 FARSA CML33, FARSL, FARSLA ENSG00000179115 Phenylalanyl-tRNA synthetase, alpha subunit 19 12922479-12934037 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001911 Approved Supported Cytosol Expressed in all cerebral cortex: 67.4 FARSB FARSLB, FRSB, PheHB ENSG00000116120 Phenylalanyl-tRNA synthetase, beta subunit 2 222570536-222656337 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA036677, HPA036678, HPA061398 Supported Supported Nucleus
Cytosol Expressed in all testis: 34.3 FPGS ENSG00000136877 Folylpolyglutamate synthase 9 127794597-127814327 Enzymes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA050488 Approved Expressed in all ovary: 26.1 GARS CMT2D, DSMAV, GlyRS, SMAD1 ENSG00000106105 Glycyl-tRNA synthetase 7 30594681-30634033 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA017896, HPA019097 Supported Supported Cytosol Expressed in all parathyroid gland: 94.3 GART PGFT, PRGS ENSG00000159131 Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 21 33503931-33543491 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA002119, HPA005779 Approved Uncertain Nucleoplasm
Mitochondria
Cytosol Expressed in all testis: 55.3 GCLC GCS, GLCL, GLCLC ENSG00000001084 Glutamate-cysteine ligase, catalytic subunit 6 53497341-53616970 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB009569, HPA036359, HPA036360 Approved Approved Nucleus
Nucleoli
Cytosol Expressed in all fallopian tube: 81.9 GLUL GLNS ENSG00000135821 Glutamate-ammonia ligase 1 182381704-182392206 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA007316, HPA007571, CAB008636 Approved Supported Mitochondria
Cytosol Expressed in all adipose tissue: 1001.1 GMPS ENSG00000163655 Guanine monophosphate synthase 3 155870536-155944026 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA046630 Approved Cytosol Expressed in all testis: 180.7 GSS ENSG00000100983 Glutathione synthetase 20 34928430-34955817 Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA054508, HPA059315 Supported Supported Nucleus Expressed in all epididymis: 104.1 HARS ENSG00000170445 Histidyl-tRNA synthetase 5 140673173-140692024 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA036539 Approved Validated Cytosol Expressed in all cerebral cortex: 71.3 HARS2 HARSL, HARSR, HO3 ENSG00000112855 Histidyl-tRNA synthetase 2, mitochondrial 5 140691426-140699291 Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA035941 Approved Approved Cytosol Expressed in all parathyroid gland: 35.8 HLCS HCS ENSG00000159267 Holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 21 36750888-36990236 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA017379 Approved Supported Cytosol Expressed in all parathyroid gland: 33.1 IARS IARS1, ILRS ENSG00000196305 Isoleucyl-tRNA synthetase 9 92210207-92293756 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA029806 Approved Supported Cytosol Expressed in all parathyroid gland: 139.0 IARS2 FLJ10326 ENSG00000067704 Isoleucyl-tRNA synthetase 2, mitochondrial 1 220094102-220148041 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA024212, HPA024594, HPA024596 Supported Validated Mitochondria Expressed in all parathyroid gland: 141.6 KARS DFNB89, KARS1, KARS2 ENSG00000065427 Lysyl-tRNA synthetase 16 75627474-75648643 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA041345, HPA041550 Supported Supported Cytosol Expressed in all testis: 177.7 LARS FLJ10595, FLJ21788, HSPC192, LARS1, LEUS, RNTLS ENSG00000133706 Leucyl-tRNA synthetase 5 146113038-146182660 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA036424, HPA040881 Supported Supported Nuclear bodies
Cytosol Expressed in all parathyroid gland: 69.4 LARS2 KIAA0028, LEURS, MGC26121 ENSG00000011376 Leucyl-tRNA synthetase 2, mitochondrial 3 45388506-45549421 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA035951, HPA045450, HPA066085 Approved Supported Nucleoplasm
Mitochondria Expressed in all parathyroid gland: 18.9 LIG1 ENSG00000105486 Ligase I, DNA, ATP-dependent 19 48115445-48170603 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB037015, HPA041431, HPA048071 Approved Supported Nucleoplasm
Golgi apparatus
Vesicles Mixed bone marrow: 21.0 LIG3 LIG2 ENSG00000005156 Ligase III, DNA, ATP-dependent 17 34980494-35009743 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA006723 Supported Supported Nucleoplasm Expressed in all testis: 38.5 LIG4 ENSG00000174405 Ligase IV, DNA, ATP-dependent 13 108207439-108218368 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001334 Supported Approved Nucleoplasm
Plasma membrane
Cytosol Mixed cerebral cortex: 20.1 MARS CMT2U, MetRS, SPG70 ENSG00000166986 Methionyl-tRNA synthetase 12 57475445-57517569 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA004125, CAB017097 Supported Approved Validated Cytosol Expressed in all testis: 66.4 MARS2 mtMetRS, SPAX3 ENSG00000247626 Methionyl-tRNA synthetase 2, mitochondrial 2 197705369-197708387 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA035589, HPA035590 Uncertain Approved Intermediate filaments
Cytosol Expressed in all lymph node: 7.6 MCCC1 MCCA ENSG00000078070 Methylcrotonoyl-CoA carboxylase 1 (alpha) 3 183015218-183116075 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA008310 Approved Validated Mitochondria Expressed in all kidney: 60.7 MCCC2 MCCB ENSG00000131844 Methylcrotonoyl-CoA carboxylase 2 (beta) 5 71587288-71658704 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA038300, HPA038301, HPA061546 Supported Validated Mitochondria Expressed in all prostate: 75.0 MTHFD1 MTHFC, MTHFD ENSG00000100714 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 14 64388031-64463457 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA000704, HPA001290, HPA015006, HPA050052 Approved Validated Cytosol Expressed in all liver: 198.3 MTHFD1L DKFZP586G1517, FLJ21145, FTHFSDC1 ENSG00000120254 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 6 150865549-151101887 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA015006, HPA029040, HPA029041, HPA050052, HPA074911 Approved Supported Mitochondria Mixed placenta: 20.5 MTHFS HsT19268 ENSG00000136371 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) 15 79833585-79897379 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA008067, HPA054177 Approved Supported Cytosol Expressed in all liver: 115.9 NADSYN1 FLJ10631 ENSG00000172890 NAD synthetase 1 11 71453109-71524107 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB017798, HPA038523, HPA038524 Approved Validated Cytosol Expressed in all spleen: 42.1 NAPRT NAPRT1, PP3856 ENSG00000147813 Nicotinate phosphoribosyltransferase 8 143574785-143578649 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA023739, HPA024017, CAB068206, CAB068207 Approved Approved Nucleus
Golgi apparatus
Cytosol Tissue enhanced 0 duodenum: 22.0;small intestine: 21.1 bone marrow: 9.7 NARS NARS1 ENSG00000134440 Asparaginyl-tRNA synthetase 18 57600656-57622213 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB034257, HPA040017 Supported Validated Cytosol Expressed in all parathyroid gland: 151.7 NARS2 DFNB94, FLJ23441, SLM5 ENSG00000137513 Asparaginyl-tRNA synthetase 2, mitochondrial (putative) 11 78435961-78574874 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA026793 Supported Approved Nucleoplasm
Mitochondria
Cytosol Expressed in all kidney: 19.7 PAICS ADE2H1, AIRC, PAIS ENSG00000128050 Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 4 56435741-56464579 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA035895, HPA041538 Uncertain Approved Cytosol Expressed in all parathyroid gland: 72.8 PARS2 DKFZp727A071 ENSG00000162396 Prolyl-tRNA synthetase 2, mitochondrial (putative) 1 54756898-54764514 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA028308, HPA028314, HPA028518 Uncertain Approved Nucleoli fibrillar center
Mitochondria Mixed testis: 8.0 PC PCB ENSG00000173599 Pyruvate carboxylase 11 66848233-66958376 Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB033742, HPA043922, HPA058765 Uncertain Validated Mitochondria Expressed in all adipose tissue: 63.7 PCCA ENSG00000175198 Propionyl CoA carboxylase, alpha polypeptide 13 100089015-100530435 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA041716, HPA047792 Supported Expressed in all epididymis: 259.8 PCCB ENSG00000114054 Propionyl CoA carboxylase, beta polypeptide 3 136250306-136337896 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA036939, HPA036940 Supported Expressed in all liver: 102.6 PFAS FGARAT, KIAA0361, PURL ENSG00000178921 Phosphoribosylformylglycinamidine synthase 17 8247618-8270491 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA022140, HPA022886 Supported Approved Nucleoplasm
Plasma membrane Expressed in all lymph node: 11.8 PPCS FLJ11838 ENSG00000127125 Phosphopantothenoylcysteine synthetase 1 42456117-42473385 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA031361, HPA031363 Approved Approved Nucleus
Nucleoli fibrillar center
Mitochondria Expressed in all thyroid gland: 110.1 QARS ENSG00000172053 Glutaminyl-tRNA synthetase 3 49095932-49105135 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA036986, HPA036987 Supported Validated Cytosol Expressed in all rectum: 121.1 QRSL1 DKFZP564C1278, FLJ10989, FLJ12189, FLJ13447, GatA ENSG00000130348 Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 6 106629578-106668417 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA029585, HPA029587 Approved Approved Vesicles
Centrosome Expressed in all lymph node: 18.9 RARS DALRD1 ENSG00000113643 Arginyl-tRNA synthetase 5 168486445-168519299 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA003979, HPA004130 Approved Validated Nucleoplasm
Cytosol Expressed in all duodenum: 55.9 RARS2 DALRD2, dJ382I10.6, MGC14993, MGC23778, PRO1992, RARSL ENSG00000146282 Arginyl-tRNA synthetase 2, mitochondrial 6 87514378-87590003 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA039987, HPA042645 Uncertain Approved Nuclear bodies
Cytosol Expressed in all testis: 56.7 RIMKLA FAM80A, MGC47816, NAAGS-II, RP11-157D18.1 ENSG00000177181 Ribosomal modification protein rimK-like family member A 1 42380795-42422578 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at transcript level Evidence at transcript level Evidence at protein level HPA027826 Uncertain Uncertain Nucleoli fibrillar center Tissue enhanced 0 cerebral cortex: 10.3 rectum: 3.9 RIMKLB FAM80B, KIAA1238, NAAGS, NAAGS-I ENSG00000166532 Ribosomal modification protein rimK-like family member B 12 8681600-8783095 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at transcript level Evidence at protein level HPA059552 Approved Nucleoplasm
Microtubule organizing center Expressed in all endometrium: 74.3 RTCA RPC, RTC1, RTCD1 ENSG00000137996 RNA 3'-terminal phosphate cyclase 1 100266207-100292769 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA027982, HPA027990, HPA028151 Uncertain Validated Nucleus Expressed in all duodenum: 36.0 RTCB C22orf28, FAAP, HSPC117 ENSG00000100220 RNA 2',3'-cyclic phosphate and 5'-OH ligase 22 32387582-32412255 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA000535, HPA001103 Supported Supported Nucleoplasm
Vesicles
Cytosol Expressed in all parathyroid gland: 102.3 SARS SERS ENSG00000031698 Seryl-tRNA synthetase 1 109213918-109238169 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA016939, HPA064668 Uncertain Validated Cytosol Expressed in all thyroid gland: 240.2 SARS2 FLJ20450, mtSerRS, SARS, SARSM, SerRSmt, SERS, SYS ENSG00000104835 Seryl-tRNA synthetase 2, mitochondrial 19 38915266-38930896 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA052730, HPA056957 Approved Expressed in all thyroid gland: 8.9 SLC27A2 ACSVL1, FACVL1, FATP2, hFACVL1, HsT17226, VLACS, VLCS ENSG00000140284 Solute carrier family 27 (fatty acid transporter), member 2 15 50182196-50236395 Enzymes, Predicted membrane proteins, Transporters Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA026089 Supported Group enriched 5 epididymis: 79.2;kidney: 160.9;liver: 145.2 placenta: 24.5 SLC27A5 ACSB, ACSVL6, FACVL3, FATP5, FLJ22987, VLACSR, VLCS-H2, VLCSH2 ENSG00000083807 Solute carrier family 27 (fatty acid transporter), member 5 19 58479512-58512413 Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA007292, CAB056160, CAB068239 Supported Tissue enriched 23 liver: 335.8 fallopian tube: 14.4 SUCLA2 ENSG00000136143 Succinate-CoA ligase, ADP-forming, beta subunit 13 47936491-48001354 Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA039435, HPA039536, HPA061528 Supported Supported Validated Mitochondria Expressed in all skeletal muscle: 78.8 SUCLG1 ENSG00000163541 Succinate-CoA ligase, alpha subunit 2 84423523-84460045 Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA036683, HPA036684 Supported Supported Plasma membrane
Mitochondria Expressed in all kidney: 467.4 SUCLG2 ENSG00000172340 Succinate-CoA ligase, GDP-forming, beta subunit 3 67360460-67654614 Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA046705, HPA051998 Supported Supported Plasma membrane
Mitochondria Expressed in all colon: 171.4 TARS ENSG00000113407 Threonyl-tRNA synthetase 5 33440696-33469539 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA037425 Approved Supported Actin filaments
Cytosol Expressed in all thyroid gland: 44.3 TARS2 FLJ12528, TARSL1 ENSG00000143374 Threonyl-tRNA synthetase 2, mitochondrial (putative) 1 150487364-150507609 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA028626 Approved Approved Nucleoplasm
Intermediate filaments
Cytosol Expressed in all parathyroid gland: 28.8 TARSL2 FLJ25005 ENSG00000185418 Threonyl-tRNA synthetase-like 2 15 101653598-101724604 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA063963, HPA066697 Uncertain Approved Cytosol Expressed in all cerebral cortex: 15.7 TRIM25 EFP, RNF147, ZNF147 ENSG00000121060 Tripartite motif containing 25 17 56887909-56914038 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA005909 Approved Approved Nucleoplasm
Nuclear bodies
Cytosol Expressed in all skin: 34.9 TTL MGC46235 ENSG00000114999 Tubulin tyrosine ligase 2 112482154-112541739 Cancer-related genes, Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA066819 Approved Nucleoplasm
Vesicles Mixed cerebral cortex: 4.5 UBA1 A1S9T, CFAP124, GXP1, POC20, UBE1, UBE1X ENSG00000130985 Ubiquitin-like modifier activating enzyme 1 X 47190861-47215128 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA000289, HPA001506, CAB019435, CAB073410 Approved Validated Nucleoplasm Expressed in all parathyroid gland: 235.0 UBA6 FLJ10808, UBE1L2 ENSG00000033178 Ubiquitin-like modifier activating enzyme 6 4 67612652-67701179 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA037001 Uncertain Validated Nucleoplasm
Cytosol Expressed in all testis: 18.6 VARS VARS2 ENSG00000204394 Valyl-tRNA synthetase 6 31777518-31795953 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA046710 Approved Validated Cytosol Mixed testis: 5.5 VARS2 DKFZP434L1435, G7a, KIAA1885, VARS2L, VARSL ENSG00000137411 Valyl-tRNA synthetase 2, mitochondrial 6 30908242-30926459 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA062449, HPA070267 Approved Approved Mitochondria Mixed esophagus: 5.2 WARS IFI53, IFP53 ENSG00000140105 Tryptophanyl-tRNA synthetase 14 100333788-100376805 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA005573, HPA018944 Validated Cytosol Expressed in all placenta: 468.8 WARS2 TrpRS ENSG00000116874 Tryptophanyl tRNA synthetase 2, mitochondrial 1 119031216-119140671 Enzymes, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA069692 Supported Supported Plasma membrane
Mitochondria Expressed in all fallopian tube: 15.2 YARS tyrRS, YRS, YTS ENSG00000134684 Tyrosyl-tRNA synthetase 1 32775237-32818153 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA017936, HPA018950, HPA018954 Supported Validated Cytosol Expressed in all cerebral cortex: 81.7 YARS2 CGI-04, FLJ13995, mt-TyrRS ENSG00000139131 Tyrosyl-tRNA synthetase 2, mitochondrial 12 32727490-32755902 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA038721, HPA057610, HPA074097 Uncertain Supported Nuclear bodies
Mitochondria Mixed placenta: 11.2