We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most testicular cancers along with several melanomas, gliomas, urothelial, colorectal, prostate, ovarian and cervical cancers displayed moderate nuclear positivity. Remaining cancer tissues were mainly negative.
Cancer tissues showed weak to moderate cytoplasmic and membranous positivity. A few liver and colorectal cancers exhibited strong immunoreactivity. Several gliomas, carcinoids, lung, cervical, urothelia, prostate and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
TNMD (HGNC Symbol)
Synonyms
BRICD4, ChM1L, myodulin, TEM, tendin
Description
Tenomodulin (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]