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Most cancers displayed moderate to strong cytoplasmic staining in several cases. Malignant gliomas, lymphomas and melanomas along with skin, testicular and cervical cancers were mainly negative.
GENE INFORMATION
Gene name
SS18L2 (HGNC Symbol)
Synonyms
KIAA-iso
Description
Synovial sarcoma translocation gene on chromosome 18-like 2 (HGNC Symbol)
Entrez gene summary
Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002]