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Most malignancies displayed weak to moderate cytoplasmic staining. Most cases of malignant lymphomas and testicular cancer along with several cases of cancers of malignant gliomas and lung cancers were negative.
Most malignant tissues displayed weak to moderate cytoplasmic staining. Malignant lymphomas, renal cancer and hepatocellular carcinomas were generally negative.
This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]