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Most cancer tissues displayed moderate cytoplasmic positivity. Strong staining was observed in several cases of testicular cancers, malignant gliomas and melanomas. Prostate cancers as well as a majority of lymphomas, gastric, pancreatic and liver cancers were weakly stained or negative.
A majority of cancers exhibited moderate to strong cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
MAP4
Synonyms
Description
Microtubule-associated protein 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
P27816 [Direct mapping] Microtubule-associated protein 4
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Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P27816 [Direct mapping] Microtubule-associated protein 4
Show all
Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P27816 [Direct mapping] Microtubule-associated protein 4
Show all
Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)