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Several malignant cells were weakly stained or negative. Testicular cancers showed strong mainly nuclear staining. Moderate to strong nuclear and/or cytoplasmic positivity was observed in malignant lymphomas, prostate, ovarian, cervical, endometrial, thyroid, urothelial and head and neck cancers.
Most malignancies showed weak to moderate nuclear and cytoplasmic immunoreactivity. Testicular cancers were strongly stained. Renal, gastric, pancreatic and liver cancers were mainly negative.
GENE INFORMATION
Gene name
USP28 (HGNC Symbol)
Synonyms
KIAA1515
Description
Ubiquitin specific peptidase 28 (HGNC Symbol)
Entrez gene summary
The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000077 [DNA damage checkpoint] GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006281 [DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008283 [cell proliferation] GO:0010212 [response to ionizing radiation] GO:0016579 [protein deubiquitination] GO:0034644 [cellular response to UV] GO:0036459 [ubiquitinyl hydrolase activity] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043234 [protein complex] GO:0061136 [regulation of proteasomal protein catabolic process]