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A majority of cancer tissues were negative. Most liver tumors were distinctly stained in cytoplasm. Secreted material, serum and tumor stroma was often positive.
Weak plasma staining in several cancer tissues. All cancer cells were negative.
GENE INFORMATION
Gene name
ITIH4 (HGNC Symbol)
Synonyms
H4P, IHRP, ITIHL1
Description
Inter-alpha-trypsin inhibitor heavy chain family, member 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]