Tissue expression of NPFFR2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NPFFR2
Gene description	Neuropeptide FF receptor 2
Protein class	G-protein coupled receptors Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (seminal vesicle, placenta)
GTEx:	Not detected
FANTOM5:	Group enriched (placenta, seminal vesicle)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (seminal vesicle, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (placenta, seminal vesicle)

GENE INFORMATION
Gene name	NPFFR2 (HGNC Symbol)
Synonyms	GPR74, NPFF2, NPGPR
Description	Neuropeptide FF receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	72031804 - 72148067
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000056291 (version 83.38)
Entrez gene	10886
UniProt	Q9Y5X5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5X5
Antibodypedia	NPFFR2 antibodies

PROTEIN BROWSER

NPFFR2-001	NPFFR2-002	NPFFR2-003	NPFFR2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPFFR2-001 ENSP00000307822 ENST00000308744	Q9Y5X5 [Direct mapping] Neuropeptide FF receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0008188 [neuropeptide receptor activity] GO:0009582 [detection of abiotic stimulus] GO:0015629 [actin cytoskeleton] GO:0016021 [integral component of membrane] GO:0031628 [opioid receptor binding] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0043408 [regulation of MAPK cascade] GO:0045761 [regulation of adenylate cyclase activity] GO:1901652 [response to peptide] GO:2000479 [regulation of cAMP-dependent protein kinase activity] Show all	522 aa 60.3 kDa	Yes	7
NPFFR2-002 ENSP00000379321 ENST00000395999	Q9Y5X5 [Direct mapping] Neuropeptide FF receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0008188 [neuropeptide receptor activity] GO:0009582 [detection of abiotic stimulus] GO:0015629 [actin cytoskeleton] GO:0016021 [integral component of membrane] GO:0031628 [opioid receptor binding] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0043408 [regulation of MAPK cascade] GO:0045761 [regulation of adenylate cyclase activity] GO:1901652 [response to peptide] GO:2000479 [regulation of cAMP-dependent protein kinase activity] Show all	423 aa 49.1 kDa	No	7
NPFFR2-003 ENSP00000351599 ENST00000358749	Q9Y5X5 [Direct mapping] Neuropeptide FF receptor 2 A0PJM9 [Target identity:100%; Query identity:100%] Neuropeptide FF receptor 2; Neuropeptide FF receptor 2, isoform CRA_b; cDNA FLJ75415, highly similar to Homo sapiens G protein-coupled receptor 74 (GPR74), transcript variant 2, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0008188 [neuropeptide receptor activity] GO:0009582 [detection of abiotic stimulus] GO:0015629 [actin cytoskeleton] GO:0016021 [integral component of membrane] GO:0031628 [opioid receptor binding] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0043408 [regulation of MAPK cascade] GO:0045761 [regulation of adenylate cyclase activity] GO:1901652 [response to peptide] GO:2000479 [regulation of cAMP-dependent protein kinase activity] Show all	420 aa 48.7 kDa	No	7
NPFFR2-004 ENSP00000340789 ENST00000344413	Q9Y5X5 [Direct mapping] Neuropeptide FF receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0008188 [neuropeptide receptor activity] GO:0009582 [detection of abiotic stimulus] GO:0015629 [actin cytoskeleton] GO:0031628 [opioid receptor binding] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0043408 [regulation of MAPK cascade] GO:0045761 [regulation of adenylate cyclase activity] GO:1901652 [response to peptide] GO:2000479 [regulation of cAMP-dependent protein kinase activity] Show all	132 aa 15.1 kDa	Yes	0