We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Moderate to strong cytoplasmic and membranous immunoreactivity was observed in malignant carcinoids and in some cases of lung-, liver-, pancreatic- and stomach cancers. Remaining malignant tissues were generally weakly stained or negative.
GENE INFORMATION
Gene name
LNX1 (HGNC Symbol)
Synonyms
LNX, MPDZ, PDZRN2
Description
Ligand of numb-protein X 1, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]