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Malignant lymphomas, colorectal, breast, endometrial and testicular cancers showed moderate to strong cytoplasmic immunoreactivity. Liver and cervical cancers along with several prostate and urothelial cancers were moderately stained. Remaining malignant cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
USP40 (HGNC Symbol)
Synonyms
FLJ10785
Description
Ubiquitin specific peptidase 40 (HGNC Symbol)
Entrez gene summary
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]