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Most cancers displayed moderate cytoplasmic staining often combined with nuclear positivity. A few cases of hepatocellular carcinomas were strongly stained. Skin cancers along with a majority of cases in melanomas, lymphomas ovarian, lung and gastric cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SULT2B1 (HGNC Symbol)
Synonyms
HSST2
Description
Sulfotransferase family, cytosolic, 2B, member 1 (HGNC Symbol)
Entrez gene summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]