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Most cancer tissues showed weak to moderate cytoplasmic staining. Most lymphomas, liver cancers and renal cancers were negative.
GENE INFORMATION
Gene name
INTS6 (HGNC Symbol)
Synonyms
DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2
Description
Integrator complex subunit 6 (HGNC Symbol)
Entrez gene summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]