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Most malignancies demonstrated weak to moderate cytoplasmic staining. A few cases of non-Hodgkins lymphoma and high grade gliomas displayed strong cytoplasmic immunoreactivity.
Malignant cells displayed moderate to strong cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
DFNA5 (HGNC Symbol)
Synonyms
ICERE-1
Description
Deafness, autosomal dominant 5 (HGNC Symbol)
Entrez gene summary
Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm] GO:0006915 [apoptotic process] GO:0007605 [sensory perception of sound] GO:0008285 [negative regulation of cell proliferation] GO:0060113 [inner ear receptor cell differentiation] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm] GO:0006915 [apoptotic process] GO:0007605 [sensory perception of sound] GO:0008285 [negative regulation of cell proliferation] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
O60443 [Direct mapping] Non-syndromic hearing impairment protein 5
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm] GO:0006915 [apoptotic process] GO:0007605 [sensory perception of sound] GO:0008285 [negative regulation of cell proliferation] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]