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Malignant tissues displayed moderate cytoplasmic positivity. Malignant gliomas as well as most testicular and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SEC23IP (HGNC Symbol)
Synonyms
p125
Description
SEC23 interacting protein (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]