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RNA tissue category: Group enriched (cerebral cortex, adrenal gland, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, brain, hippocampus, caudate, retina)
GENE INFORMATION
Gene name
SEPT4 (HGNC Symbol)
Synonyms
ARTS, CE5B3, H5, hCDCREL-2, hucep-7, MART, PNUTL2
Description
Septin 4 (HGNC Symbol)
Entrez gene summary
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]