We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer cells showed moderate cytoplasmic staining with additional nuclear positivity in many cases. Many hepatocellular carcinomas and thyroid papillary adenocarcinomas along with a few malignant melanomas and non-Hodgkins lymphomas were strongly stained. Several cervical, endometrial and prostate cancers were weakly stained or negative.
The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]