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Moderate cytoplasmic and nuclear positivity was observed in most cancers. Strong staining was observed in colorectal, renal cancers and several pancreatic, liver, prostate and endometrial cancers.
Several cases of liver, renal, thyroid and ovarian cancers showed moderate cytoplasmic immunoreactivity. The remaining cancer cells were in general weakly stained or negative.
This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]