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Melanomas, testicular, colorectal, pancreatic and ovarian cancers as well as several cases of a few other cancers displayed weak to moderate cytoplasmic and/or nuclear membranous staining. Other cancer cells were generally negative.
GENE INFORMATION
Gene name
PCDH12 (HGNC Symbol)
Synonyms
VE-cadherin-2
Description
Protocadherin 12 (HGNC Symbol)
Entrez gene summary
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth. [provided by RefSeq, Jul 2008]