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A few thyroid cancers showed strong staining. Several hepatocellular and prostate cancers as well as fractions of malignant melanomas and pancreatic cancers showed weak to moderate cytoplasmic positivity. Remaining malignant cells were in general negative.
GENE INFORMATION
Gene name
GLS (HGNC Symbol)
Synonyms
GLS1, KIAA0838
Description
Glutaminase (HGNC Symbol)
Entrez gene summary
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)