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Cancer tissues displayed moderate nuclear and cytoplasmic positivity. Few cases of colorectal, pancreatic, prostate, ovarian and lung cancers showed strong staining.
GENE INFORMATION
Gene name
RBBP5 (HGNC Symbol)
Synonyms
RBQ3, SWD1
Description
Retinoblastoma binding protein 5 (HGNC Symbol)
Entrez gene summary
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]