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A majority of adenocarcinomas as well as cholangiocarcinomas in liver showed distinct staining in luminal membranes often combined with immunoreactivity in the apical part of the cytoplasm. Most of the remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
TSPAN1 (HGNC Symbol)
Synonyms
NET-1, TSPAN-1
Description
Tetraspanin 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]