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Strong cytoplasmic or nuclear membranous staining was observed in a few malignant carcinoids. A rare case of cholangiocarcinoma showed strong positivity. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
PPP1R3C (HGNC Symbol)
Synonyms
PPP1R5, PTG
Description
Protein phosphatase 1, regulatory subunit 3C (HGNC Symbol)
Entrez gene summary
This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals. [provided by RefSeq, Oct 2011]