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A few cases of low grade non-Hodgkin's lymphomas displayed strong cytoplasmic immunoreactivity. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
HVCN1 (HGNC Symbol)
Synonyms
Hv1, MGC15619, VSOP
Description
Hydrogen voltage gated channel 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]