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Most malignancies displayed moderate to strong cytoplasmic and membranous positivity. Prostate cancers and lymphomas were in general weakly stained or negative.
GENE INFORMATION
Gene name
TREM1 (HGNC Symbol)
Synonyms
CD354, TREM-1
Description
Triggering receptor expressed on myeloid cells 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]