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A majority of cancer tissues displayed weak to moderate cytoplasmic immunoreactivity. Lymphomas and a few cases of urothelial cancers were strongly stained. Several cases of cervical squamous cell carcinomas, hepatocellular and renal cancers were negative.
GENE INFORMATION
Gene name
CPNE5 (HGNC Symbol)
Synonyms
COPN5, CPN5, KIAA1599
Description
Copine V (HGNC Symbol)
Entrez gene summary
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. More variants may exist, but their full-length natures could not be determined. [provided by RefSeq, Sep 2015]