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Cases of breast, prostate and endometrial cancers showed moderate cytoplasmic positivity. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
GAL3ST1 (HGNC Symbol)
Synonyms
CST
Description
Galactose-3-O-sulfotransferase 1 (HGNC Symbol)
Entrez gene summary
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma. [provided by RefSeq, Jul 2008]