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Malignant cells showed weak cytoplasmic staining or were negative. Hepatocellular carcinomas showed moderate to strong cytoplasmic staining. Malignant carcinoids along with several cholangiocarcinomas, malignant melanomas, lung and ovarian cancers were moderately stained.
GENE INFORMATION
Gene name
GGT7 (HGNC Symbol)
Synonyms
D20S101, dJ18C9.2, GGTL3, GGTL5
Description
Gamma-glutamyltransferase 7 (HGNC Symbol)
Entrez gene summary
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]