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HRSP12

GENERAL INFORMATION

Gene name

 HRSP12

Gene description

 Heat-responsive protein 12

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (liver, kidney)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in a few cell types, most abundant in hepatocytes and proximal renal tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA022856 , HPA023489
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HRSP12 (HGNC Symbol)

Synonyms

 P14.5, PSP, UK114

Description

 Heat-responsive protein 12 (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 q22.2

Chromosome location (bp)

 98102344 - 98117241

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132541 (version 83.38)

Entrez gene

 10247

UniProt

 P52758 (UniProt - Evidence at protein level)

neXtProt

 NX_P52758

Antibodypedia

 HRSP12 antibodies

PROTEIN BROWSER
HRSP12-001
HRSP12-003
HRSP12-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HRSP12-001
ENSP00000254878
ENST00000254878
P52758 [Direct mapping]
Ribonuclease UK114
A0A024R9H2 [Target identity:100%; Query identity:100%]
Heat-responsive protein 12, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005829 [cytosol]
GO:0006449 [regulation of translational termination]
GO:0007420 [brain development]
GO:0016892 [endoribonuclease activity, producing 3'-phosphomonoesters]
GO:0017148 [negative regulation of translation]
GO:0019239 [deaminase activity]
GO:0030324 [lung development]
GO:0033993 [response to lipid]
GO:0036041 [long-chain fatty acid binding]
GO:0042803 [protein homodimerization activity]
GO:0043167 [ion binding]
GO:0044822 [poly(A) RNA binding]
GO:0046914 [transition metal ion binding]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0070062 [extracellular exosome]
GO:0070314 [G1 to G0 transition]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:1902074 [response to salt]
GO:1904012 [platinum binding]
GO:1904013 [xenon atom binding]
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 137 aa
14.5 kDa 		No 0
HRSP12-003
ENSP00000430482
ENST00000521560
H0YBX3 [Direct mapping]
Ribonuclease UK114
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0019239 [deaminase activity]
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 127 aa
13.7 kDa 		Yes 0
HRSP12-007
ENSP00000428596
ENST00000520507
H0YB34 [Direct mapping]
Ribonuclease UK114
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0019239 [deaminase activity]
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 148 aa
15.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.