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Endometrial, thyroid and a majority of colorectal and prostate cancers showed moderate granular or dot-like immunoreactivity. The remaining cancer tissues were generally negative.
Most caner tissues were generally negative or showed weak nuclear immunoreactivity.
GENE INFORMATION
Gene name
IPO8 (HGNC Symbol)
Synonyms
IMP8, RANBP8
Description
Importin 8 (HGNC Symbol)
Entrez gene summary
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)