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Malignant cells generally showed moderate cytoplasmic positivity. Most cases of malignant gliomas and lymphomas along with skin, cervical and renal cancers were weakly stained or negative.
Moderate to strong cytoplasmic immunoreactivity was observed in a majority of malignant cells. Most gliomas and lymphomas showed strong nuclear positivity, whereas squamous cell carcinomas of skin and testicular cancers exhibited strong nucleolar staining.
GENE INFORMATION
Gene name
LRP4 (HGNC Symbol)
Synonyms
CLSS, LRP-4, MEGF7, SOST2
Description
Low density lipoprotein receptor-related protein 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]