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Most cancers displayed weak to moderate cytoplasmic immunoreactivity. Nuclear positivity was observed in subsets of cells in several malignancies e.g. squamous cell carcinomas, breast, testicular and colorectal cancers. Most liver cancers along with few squamous cell carcinomas and renal cancers were negative.
GENE INFORMATION
Gene name
MDH1B (HGNC Symbol)
Synonyms
FLJ25341, RP11-95H11
Description
Malate dehydrogenase 1B, NAD (soluble) (HGNC Symbol)
GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] GO:0006108 [malate metabolic process] GO:0016615 [malate dehydrogenase activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process]