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Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000975 [regulatory region DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006909 [phagocytosis] GO:0006955 [immune response] GO:0009617 [response to bacterium] GO:0019221 [cytokine-mediated signaling pathway] GO:0030099 [myeloid cell differentiation] GO:0032729 [positive regulation of interferon-gamma production] GO:0032735 [positive regulation of interleukin-12 production] GO:0042742 [defense response to bacterium] GO:0042832 [defense response to protozoan] GO:0044130 [negative regulation of growth of symbiont in host] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071222 [cellular response to lipopolysaccharide]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated]