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Tumour tissues displayed moderate cytoplasmic, nuclear and membranous positivity. A few cases of gliomas, lung, urothelial and liver cancers were strongly stained.
Tumour cells were in general negative. Several cases of prostate cancers and a few testicular cancers showed weak to moderate cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
FBXL17 (HGNC Symbol)
Synonyms
DKFZP434C1715, Fbl17, Fbx13, FBXO13
Description
F-box and leucine-rich repeat protein 17 (HGNC Symbol)
Entrez gene summary
Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]