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Cancer cells displayed weak to moderate cytoplasmic positivity. Gliomas and lymphomas as well as several cases of renal, testicular and urothelial cancers were negative.
Several cases of ovarian cancers along with occasional cases of embryonal cancers of testis showed moderate to strong cytoplasmic staining. Endometrial cancers along with few cases of renal, pancreas and liver cancers displayed moderate to strong cytoplasmic and membranous positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
DCDC2 (HGNC Symbol)
Synonyms
DCDC2A, KIAA1154, NPHP19, RU2
Description
Doublecortin domain containing 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]