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A majority of malignant tissues showed weak to moderate cytoplasmic positivity. Several cases of colorectal cancers and cases of malignant gliomas and endometrial cancers exhibited strong staining. Malignancies in testis were negative.
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]