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Tumour tissues displayed weak to moderate cytoplasmic positivity. Several cases of endometrial, thyroid, lung, testicular, pancreatic and liver cancers exhibited strong immunoreactivity. Many cases of gliomas and lymphomas were negative.
Several cases of hepatocellular carcinomas showed moderate cytoplasmic staining while a few cases of endometrial and pancreatic cancers showed moderate to strong cytoplasmic staining. Remaining malignant cells were generally negative.
GENE INFORMATION
Gene name
SERPING1 (HGNC Symbol)
Synonyms
C1-INH, C1IN, C1NH, HAE1, HAE2
Description
Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]