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PDE3B

GENERAL INFORMATION

Gene name

 PDE3B

Gene description

 Phosphodiesterase 3B, cGMP-inhibited

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adipose tissue)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDE3B (HGNC Symbol)

Synonyms

 HcGIP1

Description

 Phosphodiesterase 3B, cGMP-inhibited (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 p15.2

Chromosome location (bp)

 14643723 - 14872044

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000152270 (version 83.38)

Entrez gene

 5140

UniProt

 Q13370 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13370

Antibodypedia

 PDE3B antibodies

PROTEIN BROWSER
PDE3B-001
PDE3B-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDE3B-001
ENSP00000282096
ENST00000282096
Q13370 [Direct mapping]
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004119 [cGMP-inhibited cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0031018 [endocrine pancreas development]
GO:0032045 [guanyl-nucleotide exchange factor complex]
GO:0032869 [cellular response to insulin stimulus]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0042593 [glucose homeostasis]
GO:0043422 [protein kinase B binding]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0050995 [negative regulation of lipid catabolic process]
Show all
 1112 aa
124.3 kDa 		No 6
PDE3B-002
ENSP00000388644
ENST00000455098
Q13370 [Direct mapping]
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004119 [cGMP-inhibited cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0032045 [guanyl-nucleotide exchange factor complex]
GO:0032869 [cellular response to insulin stimulus]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0043422 [protein kinase B binding]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0050995 [negative regulation of lipid catabolic process]
Show all
 1061 aa
118.8 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.