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A majority of tumour cells displayed weak to moderate nuclear positivity with additional cytoplasmic staining in some cases. Renal and gastric cancer as well as most cases of malignant lymphomas were negative.
Most tumour tissues showed moderate nuclear/nuclear membranous positivity. Occasional hepatocellular carcinomas showed strong immunoreactivity. Testicular, prostate cancers along with many lymphomas, gliomas, few endometrial cancers and renal cell carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
SORBS2 (HGNC Symbol)
Synonyms
ARGBP2, KIAA0777
Description
Sorbin and SH3 domain containing 2 (HGNC Symbol)
Entrez gene summary
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]