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Most cases of melanomas displayed moderate to strong cytoplasmic positivity with additional nuclear staining in many cases. A rare case of carcinoid showed strong cytoplasmic staining. Papillary adenocarcinomas of thyroid and a few prostate cancers along with occasional non-Hodgkins lymphomas were moderately stained. Remaining cancer cells were weakly stained or negative.
GENE INFORMATION
Gene name
GDF6 (HGNC Symbol)
Synonyms
BMP13, KFS, KFS1, SGM1
Description
Growth differentiation factor 6 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008]