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Strong cytoplasmic positivity was observed in a rare cases of hepatocellular carcinoma. A few seminomas, melanomas, colorectal, urothelial and breast cancers showed weak to moderate staining. Remaining tumour cells were negative.
Lymphomas displayed strong nuclear and cytoplasmic staining. Remaining tumour cells were in general negative.
GENE INFORMATION
Gene name
NCF1 (HGNC Symbol)
Synonyms
NCF1A, NOXO2, p47phox, SH3PXD1A
Description
Neutrophil cytosolic factor 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]