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The majority of cancer tissues showed weak to moderate cytoplasmic and/or membranous positivity. Carcinoids, gliomas, lymphomas, urothelial and testicular cancers were mainly negative.
GENE INFORMATION
Gene name
TCHH (HGNC Symbol)
Synonyms
THH
Description
Trichohyalin (HGNC Symbol)
Entrez gene summary
Trichohyalin confers mechanical strength to the hair follicle inner root sheath and to other toughened epithelial tissues, such as the hard palate and filiform ridges of the tongue, by forming multiple complex crosslinks with itself and with other structural proteins (Steinert et al., 2003 [PubMed 12853460]).[supplied by OMIM, Dec 2009]