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Moderate to strong cytoplasmic staining was observed in several cases of colorectal, endometrial, ovarian and breast cancers along with occasional cases of carcinoid, lung, prostate and pancreatic cancers. Remaining cancer tissues were negative.
A majority of colorectal, breast, lung and pancreatic cancers as well as cancers of the female genital tract showed moderate to strong cytoplasmic staining. Remaining cancers were generally negative.
GENE INFORMATION
Gene name
TFF3 (HGNC Symbol)
Synonyms
HITF, ITF
Description
Trefoil factor 3 (intestinal) (HGNC Symbol)
Entrez gene summary
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]