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The majority of malignancies showed weak to moderate cytoplasmic positivity. Malignant lymphomas, prostate, skin, testicular and gastric cancers were mainly negative. Strong positivity was observed in a few cases of malignant melanomas, lung and endometrial cancers.
GENE INFORMATION
Gene name
PDE9A
Synonyms
Description
Phosphodiesterase 9A (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]