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Most malignant cells displayed moderate to strong cytoplasmic immunoreactivity with a granular pattern. A few cases of malignant gliomas were weakly stained.
A majority of malignant cells displayed moderate to strong cytoplasmic staining with a granular pattern. Several cases of malignant gliomas, thyroid and renal cancers were weakly stained or negative.
A majority of malignant cells showed moderate cytoplasmic immunoreactivity. A few cases of malignant melanomas were strongly stained. A majority of malignant gliomas, renal, skin, lung and cervical cancers were negative or weakly stained.
The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]