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CYP3A4
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TISSUE ATLAS PRIMARY DATA LIVER

GENE/PROTEIN

Antibody validation


Dictionary

Liver

Tissue proteome

Liver

LIVER - Expression summary

Protein expressioni

The protein expression bar, with the units not detected (n), low (l), medium (m) and high (h), is based on a best estimate of the true protein expression for proteins where the antibody staining pattern has been analyzed by knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. For details, see Assays & annotation.

h
m
l
n

RNA expressioni

RNA expression shows average values based on RNA-seq data generated by HPA, the Genotype-Tissue Expression (GTEx) consortium or the FANTOM5 consortium.

Read more

HPA:2446.6TPM
GTEx:356.4RPKM
FANTOM5:4187.0Tags Per Million

LIVER - Annotated protein expressioni

The detailed normal tissue page shows images of the stained tissue, together with antibody staining and expression level of the cell types. A knowledge-based annotated protein expression is provided for each cell type at the top of the page and the staining level of the individual antibodies is given underneath each antibody ID.

Samples from up to three different individuals have been stained for each antibody. The gender, age and tissue characterization are reported for each individual (patient) and are viewable when clicking on the image for magnification.

The images can be clicked for an enlarged view that can be panned. From the enlarged view, all stained images for all antibodies can be browsed (represented by miniature images). The miniature image with an orange overlay is the currently displayed image.

For histological reference, view the histological dictionary.

Annotated protein
expression

Bile duct cells:Not detected
Hepatocytes:High
 

Antibody stainingi

This score describes the level of antibody staining observed in the annotated cell types as not detected, low, medium, or high. It is based on the staining intensity and fraction of stained cells.

Read more

Antibody CAB033671

 

Bile duct cells

Not detected  

Hepatocytes

High  
 
 
 

LIVER - HPA RNA-seqi

The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.

Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. TPM (transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.

Read more

Average TPM

2446.6

N/A Female, age 60
Sample 1
TPM: 1099.8
overview Male, age 54
Sample 2
TPM: 2355.3
Cell types%
Hepatocytes: 80
Fibroblasts: 15
Other cell types: 5
overview Male, age 74
Sample 3
TPM: 974.0
Cell types%
Hepatocytes: 85
Fibroblasts: 5
Other cell types: 10
overview Female, age 62
Sample 4
TPM: 4369.5
Cell types%
Hepatocytes: 70
Fibroblasts: 10
Other cell types: 20
overview Male, age 78
Sample 5
TPM: 2071.4
Cell types%
Hepatocytes: 75
Fibroblasts: 5
Other cell types: 20
overview Male, age 53
Sample 6
TPM: 1565.4
Cell types%
Hepatocytes: 80
Fibroblasts: 5
Other cell types: 15
overview Male, age 77
Sample 7
TPM: 1715.5
Cell types%
Hepatocytes: 75
Fibroblasts: 5
Other cell types: 20
overview Female, age 72
Sample 8
TPM: 3152.3
Cell types%
Hepatocytes: 50
Fibroblasts: 10
Other cell types: 40
overview Male, age 70
Sample 9
TPM: 2666.9
Cell types%
Hepatocytes: 65
Fibroblasts: 10
Other cell types: 25
overview Female, age 23
Sample 10
TPM: 4495.8
Cell types%
Hepatocytes: 70
Fibroblasts: 5
Other cell types: 25

LIVER - GTEx RNA-seqi

RNA-Seq data is reported as average RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found on the GTEx portal.

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. RPKM values of the individual samples are presented next to the box plot.

Read more

Average RPKM

356.4

GTEx sample id

RPKM

 

Liver

Liver
RPKM: 356.4
Samples: 119

Max RPKM: 4881
Min RPKM: 0.1
Std RPKM: 551
Median RPKM: 247.3
GTEX-R53T-0326-SM-48FEC 4881.0
GTEX-X4EO-1126-SM-4QARQ 2477.3
GTEX-ZVT4-0626-SM-5E45T 1450.7
GTEX-1399R-1226-SM-5P9GF 1258.2
GTEX-U3ZN-0226-SM-3DB8D 1179.0
GTEX-13O3O-1826-SM-5IFGW 979.8
GTEX-ZYT6-0626-SM-5E45V 955.6
GTEX-YFC4-1526-SM-5IFJS 947.0
GTEX-YECK-1926-SM-4W21H 885.1
GTEX-ZVT3-1626-SM-5GU66 853.2
GTEX-131YS-1626-SM-5HL6C 848.0
GTEX-RN64-1826-SM-48FDV 827.6
GTEX-RWSA-1426-SM-47JXA 821.3
GTEX-RNOR-1426-SM-48FDJ 821.0
GTEX-12WSM-0726-SM-5GCOW 758.8
GTEX-12WSD-1426-SM-5GCN9 695.6
GTEX-RTLS-1326-SM-46MUN 692.1
GTEX-SJXC-1226-SM-4DM78 627.3
GTEX-13112-1426-SM-5EGH8 600.5
GTEX-ZF2S-3026-SM-4WWCH 597.9
GTEX-11ZVC-0726-SM-5FQT9 589.0
GTEX-147F4-1426-SM-5LUA8 573.1
GTEX-ZF29-2026-SM-4WWB7 561.5
GTEX-139TS-1426-SM-5IFJD 520.7
GTEX-14A5I-1726-SM-5QGQ5 504.7
GTEX-XBEC-1526-SM-4AT68 500.0
GTEX-PX3G-0826-SM-48TZS 488.8
GTEX-131XH-0626-SM-5LZWH 464.2
GTEX-QEG4-1826-SM-4R1JN 460.9
GTEX-14DAQ-1726-SM-5S2R2 456.3
GTEX-13PVR-0126-SM-5S2PY 437.4
GTEX-13VXU-0926-SM-5IFFH 412.4
GTEX-11NUK-1226-SM-5P9GM 397.4
GTEX-11DXZ-0126-SM-5EGGY 396.7
GTEX-11WQC-0726-SM-5EQMR 385.6
GTEX-REY6-1226-SM-48FDR 380.8
GTEX-13NYB-1026-SM-5IFH3 380.3
GTEX-QESD-2026-SM-447BI 363.3
GTEX-14AS3-0126-SM-5Q5F4 361.7
GTEX-OOBJ-0826-SM-3NB2K 345.6
GTEX-14E1K-0326-SM-5S2PE 344.1
GTEX-XOTO-0826-SM-4B65O 342.6
GTEX-11ZUS-2526-SM-59872 329.6
GTEX-11ZTS-1426-SM-5EQMM 327.7
GTEX-1212Z-0226-SM-59HLF 325.3
GTEX-WZTO-0626-SM-4PQYY 323.9
GTEX-13FTZ-0726-SM-5IFFY 318.3
GTEX-11DXY-0526-SM-5EGGQ 316.1
GTEX-13OW6-2626-SM-5IFF2 308.3
GTEX-P78B-1326-SM-3P611 288.4
GTEX-145LU-1326-SM-5LU9N 281.9
GTEX-1399T-0826-SM-5IFES 280.9
GTEX-145MF-0826-SM-5QGQA 275.8
GTEX-14753-1626-SM-5NQ9L 275.5
GTEX-11NV4-1326-SM-5HL6V 272.5
GTEX-13QJC-0726-SM-5RQJK 270.1
GTEX-13SLX-1226-SM-5S2Q6 260.9
GTEX-11GSP-0626-SM-5986T 259.3
GTEX-T6MN-1226-SM-3NMA5 254.9
GTEX-147JS-1126-SM-5RQIW 247.3
GTEX-ZAB5-0426-SM-5CVMI 240.8
GTEX-13FLV-0326-SM-5N9DJ 237.7
GTEX-Z9EW-0426-SM-5CVM9 233.7
GTEX-11EQ9-0526-SM-5A5JZ 220.2
GTEX-12WSI-0226-SM-5GCNA 214.8
GTEX-Q2AG-1126-SM-48U1P 198.9
GTEX-12ZZZ-1326-SM-59HKW 194.2
GTEX-X3Y1-2726-SM-4PQZH 190.0
GTEX-RM2N-1926-SM-48FCU 184.6
GTEX-Y5V5-0926-SM-4VBPZ 146.8
GTEX-RU72-1426-SM-46MUF 127.4
GTEX-ZTPG-1426-SM-51MT3 123.6
GTEX-UPIC-0926-SM-4IHLV 121.4
GTEX-1269C-0626-SM-5FQSS 118.9
GTEX-WYVS-1926-SM-4PQZ2 114.4
GTEX-WFON-1726-SM-4LVMQ 112.3
GTEX-11OF3-0726-SM-5BC4Z 111.2
GTEX-Y5LM-0426-SM-4VBRO 106.1
GTEX-QEL4-1226-SM-447A4 103.0
GTEX-X4EP-1026-SM-4QAS5 102.5
GTEX-13N2G-0926-SM-5IFGJ 97.7
GTEX-ZVP2-0626-SM-51MSO 94.1
GTEX-QV44-0326-SM-4R1KD 91.1
GTEX-12696-0826-SM-5EGGE 90.7
GTEX-13113-1326-SM-5GCOI 79.8
GTEX-YEC4-0826-SM-5P9FV 79.8
GTEX-139TU-0826-SM-5IJFG 63.8
GTEX-Q734-0326-SM-48U15 58.0
GTEX-S32W-1926-SM-4AD63 53.8
GTEX-13N11-0926-SM-5IJG2 53.4
GTEX-ZZPU-0426-SM-5GZYH 43.0
GTEX-12KS4-1326-SM-5LUB3 36.1
GTEX-X261-1726-SM-4PQYT 28.8
GTEX-12WSG-0626-SM-5FQTQ 25.2
GTEX-X4XY-1626-SM-46MVN 24.4
GTEX-13FTW-1126-SM-5J2NV 23.7
GTEX-14C38-1526-SM-5RQJ7 23.1
GTEX-145MO-2326-SM-5NQ9K 19.5
GTEX-S4Z8-0526-SM-4AD4T 18.2
GTEX-ZAB4-0826-SM-5LU9D 17.9
GTEX-QDVN-0826-SM-48TZ2 17.5
GTEX-WQUQ-1926-SM-4OOSA 16.7
GTEX-UPK5-1426-SM-4JBHH 16.2
GTEX-ZYY3-0626-SM-5NQ6W 13.2
GTEX-146FH-1526-SM-5NQBU 12.6
GTEX-139YR-0226-SM-5IFEM 12.4
GTEX-131XE-0326-SM-5LZVO 11.5
GTEX-ZPU1-0826-SM-57WG2 11.2
GTEX-132NY-0926-SM-5P9G3 8.5
GTEX-YB5E-0326-SM-5IFHU 7.2
GTEX-UTHO-2426-SM-4JBHD 5.1
GTEX-TKQ2-1726-SM-4DXUP 3.6
GTEX-12WSL-0226-SM-5CVMJ 3.2
GTEX-VUSG-0126-SM-4KL1X 2.3
GTEX-S33H-1626-SM-4AD68 2.0
GTEX-13NZ9-1326-SM-5MR3V 1.4
GTEX-13NZB-0626-SM-5IFH6 0.9
GTEX-144GM-1326-SM-5LU5E 0.4
GTEX-1497J-0726-SM-5Q5D1 0.1
Show all

LIVER - FANTOM5 CAGEi

Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found here.

Read more

Average Tags Per Million

4187.0

FANTOM5 sample id

Sample description

Tags Per Million

Liver
Tags Per Million: 4187.0
FF:10018-101C9 64,69,70 years, mixed 4187.0

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