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Cancers exhibited moderate to strong cytoplasmic and nuclear positivity in most cases.
GENE INFORMATION
Gene name
SQSTM1 (HGNC Symbol)
Synonyms
A170, OSIL, p60, p62, p62B, PDB3
Description
Sequestosome 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]