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A majority of cancer tissues showed weak to moderate cytoplasmic staining. Thyroid cancers and a few cases of testicular cancers were strongly stained. Several malignant lymphomas, malignant gliomas, lung, skin and renal cancers were negative.
GENE INFORMATION
Gene name
ITIH3 (HGNC Symbol)
Synonyms
H3P
Description
Inter-alpha-trypsin inhibitor heavy chain 3 (HGNC Symbol)
Entrez gene summary
This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. [provided by RefSeq, Jul 2015]
Q06033 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H3
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)